Onyonyo ahụike na-enyekarị aka n'ịchọpụta na ịgwọ ọrịa kansa. Karịsịa, magnetik resonance imaging (MRI) na-ejikarị eme ihe n'ihi mkpebi ya dị elu, karịsịa na ndị ọrụ dị iche.
Ọmụmụ ihe ọhụrụ e bipụtara n'akwụkwọ akụkọ Advanced Science na-akọ banyere onye na-ahụ maka mgbanwe nanoscale nke na-atụgharị onwe ya nke nwere ike inye aka iji anya nke uche hụ etuto ahụ n'ụzọ zuru ezu site na MRI.
Gịnị bụ ọdịichemgbasa ozi?
Mgbasa ozi dị iche (nke a makwaara dị ka mgbasa ozi dị iche) bụ kemịkalụ a na-agbaba (ma ọ bụ were) n'ime anụ ahụ ma ọ bụ akụkụ mmadụ iji kwalite nlele onyonyo. Nkwadebe ndị a dị oke ma ọ bụ dị ala karịa anụ ahụ gbara ya gburugburu, na-emepụta ọdịiche nke eji egosipụta ihe oyiyi na ngwaọrụ ụfọdụ. Dịka ọmụmaatụ, a na-ejikarị nkwadebe iodine, barium sulfate, wdg maka nlele X-ray. A na-agbanye ya n'ime arịa ọbara onye ọrịa site na sirinji ọdịiche dị elu.
Na nanoscale, ụmụ irighiri ihe na-adịgide n'ime ọbara ruo ogologo oge ma nwee ike ịbanye na etuto siri ike na-ebuteghị usoro mgbanarị ahụ kpọmkwem nke tumor. A mụọla ọtụtụ ogige molekụla dabere na nanomolecules dị ka ndị nwere ike ibu CA n'ime etuto ahụ.
A ga-ekesa ndị nnọchi anya nanoscale iche nanoscale (NCAs) nke ọma n'etiti ọbara na anụ ahụ nke mmasị iji belata mkpọtụ ndabere wee nweta oke mgbama na mkpọtụ (S/N). N'ebe dị elu, NCA na-anọgide na-adị n'ọbara ruo ogologo oge, si otú ahụ na-amụba ohere nke nnukwu fibrosis n'ihi ntọhapụ nke ion gadolinium site na mgbagwoju anya.
N'ụzọ dị mwute, ọtụtụ NCA ndị a na-eji ugbu a nwere mgbakọ dị iche iche nke ụmụ irighiri ihe dị iche iche. N'okpuru ọnụ ụzọ ụfọdụ, micelles ma ọ bụ mkpokọta na-enwekarị ikewapụ, na nsonaazụ mmemme a amabeghị.
Nchọpụta nke a sitere n'ike mmụọ nsọ n'ime macromolecules nanoscale na-atụgharị onwe ya nke na-enweghị ọnụ ụzọ nkewa dị oke mkpa. Ndị a nwere isi abụba na oyi akwa dị n'elu soluble nke na-egbochikwa mmegharị nke nkeji soluble n'ofe kọntaktị. Nke a nwere ike mechaa metụta parampat ntụrụndụ molekụla yana ọrụ ndị ọzọ enwere ike ịmegharị iji kwalite nnyefe ọgwụ yana njirimara akọwapụtara na vivo.
A na-agbanyekarị usoro mgbasa ozi dị iche n'ime ahụ onye ọrịa site na injector dị elu dị iche.LnkMed, onye na-emepụta ọkachamara na-elekwasị anya na nyocha na mmepe nke ndị na-emepụta ihe dị iche iche na-akwado ihe oriri, erewo ya.CT, MRI, naDSAinjectors n'ụlọ na ná mba ọzọ na a ghọtara na ahịa n'ọtụtụ mba. Ụlọ ọrụ anyị nwere ike inye nkwado niileihe eji eme ihena-ewu ewu ugbu a n'ụlọ ọgwụ. Ụlọ ọrụ anyị nwere usoro nyocha nke ọma maka mmepụta ngwaahịa, nnyefe ngwa ngwa, yana ọrụ zuru oke ma rụọ ọrụ nke ọma. Ndị ọrụ niile nkeLnkMedna-atụ anya isonye na ụlọ ọrụ angiography n'ọdịnihu, nọgide na-emepụta ngwaahịa dị elu maka ndị ahịa, na-elekọta ndị ọrịa.
Kedu ihe nyocha ahụ na-egosi?
A na-ewebata usoro ọhụrụ na NCA nke na-eme ka ọnọdụ ntụrụndụ ogologo nke protons dịkwuo elu, na-enye ya ohere ịmepụta ihe oyiyi dị nkọ na nnukwu ibu nke ogige gadolinium. Ngwunye ala na-ebelata ihe ize ndụ nke mmetụta ọjọọ n'ihi na dose nke CA dị ntakịrị.
N'ihi ihe onwunwe na-atụgharị onwe ya, SMDC na-esi na ya pụta nwere nnukwu isi na gburugburu ebe mgbagwoju anya. Nke a na-abawanye izu ike ka enwere ike machibido mmegharị ime na nke akụkụ gburugburu interface SMDC-Gd.
NCA a nwere ike ịgbakọta n'ime etuto ahụ, na-eme ka o kwe omume iji Gd neutron catch therapy iji gwọọ etuto ahụ kpọmkwem na nke ọma. Ka ọ dị ugbu a, emebeghị nke a n'ụlọ ọgwụ n'ihi enweghị nhọrọ iji nyefee 157Gd na etuto ahụ ma debe ya na mkpokọta kwesịrị ekwesị. Ọ dị mkpa ịgbanye nnukwu doses na-ejikọta ya na mmetụta ọjọọ na ihe ndị na-adịghị mma n'ihi na nnukwu ego nke gadolinium gbara ya gburugburu na-echebe ya pụọ na ikpughe neutron.
Nanoscale na-akwado nchịkọta nhọrọ ọgwụgwọ na nkesa kachasị mma nke ọgwụ n'ime etuto ahụ. Ụmụ irighiri ihe ndị dị nta nwere ike ịpụ apụ na capillaries, na-ebute ọrụ antitumor dị elu.
"Nyere na dayameta nke SMDC erughị 10 nm, nchoputa anyị nwere ike ịmalite site na ntinye miri emi nke SMDC n'ime etuto ahụ, na-enyere aka ịgbanahụ mmetụta nchebe nke neutrons thermal na hụ na mgbasa ozi nke electrons na gamma na-arụ ọrụ nke ọma mgbe mkpughe neutron na-ekpo ọkụ."
Gịnị bụ mmetụta?
"Enwere ike ịkwado mmepe nke SMDC kachasị mma maka nchọpụta ụbụrụ ka mma, ọbụlagodi mgbe achọrọ ọtụtụ injections MRI."
"Nchọpụta anyị na-akọwapụta ikike ịmezi NCA nke ọma site na imepụta mkpụrụ ndụ ihe nketa onwe ya ma gosipụta nnukwu ọganihu n'iji NCA na nyocha na ọgwụgwọ ọrịa cancer."
Oge nzipu: Dec-08-2023
